This study examined the ethnobotanical utilization pattern of Entandrophragma angolense and Entandrophragma utile, two notable species from the Meliaceae family with the aim of bridging the knowledge gaps in their uses and techniques in Ibadan Metropolis, Nigeria. Data for the study were collected through an ethnobotanical survey of 150 participants who are knowledgeable in traditional medicine and the use of E. angolense and E. utile with the use of a bilingual semi-structured questionnaire. Data were analyzed using descriptive statistics and ethnobotanical indices, including use-value (UV) and relative frequency of citation (RFC). The results revealed that E. utile is more commonly known and used than E. angolense, with a wide range of applications for treating multiple diseases and infections and both species are primarily harvested from the wild and their stem bark being the most commonly used part. The majority of the respondents administer these species orally, with the most common daily dosage being three times per day for E. utile and twice per day for E. angolense. Although most of the respondents reported that there is no side effects from using both species. But for the few who reported a side effect - vomiting was the most commonly reported side effect among those who did experience side effects. The study highlighted the need for education, sustainable practices, and further research to ensure safe use, continued availability, and scientific evaluation of the pharmacological profile of both species, and despite limitations, the study significantly contributes to the documentation of oral traditional knowledge related to these medicinal plants.